PROTAC Hsp90α degrader 1

PROTAC Hsp90α degrader 1 (Compound X10g) is a selective PROTAC Hsp90α degrader. PROTAC Hsp90α degrader 1 can be used for breast cancer research. PROTAC Hsp90α degrader 1 inhibits the proliferation of MDA-MB-231, MDA-MB-468, MCF-7, MX-1 cells with IC50s of 51.48 μM, 16.46 μM, 8.93 μM, 11.95 μM respectively[1].

Product Specifications

CAS Number

[3031078-90-4]

UNSPSC

12352005

Target

HSP; PROTACs

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-hsp90α-degrader-1.html

Purity

98.30

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C(N2CC3=CC=C(CN4CCN(CCCCCCC(NC5=C6C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)=CC=C5)=O)CC4)C=C3C2)=O)C=C1C(C)C

Molecular Formula

C43H50N6O7

Molecular Weight

762.89

References & Citations

[1]Jiang Q, et al. Discovery of X10g as a selective PROTAC degrader of Hsp90α protein for treating breast cancer. Eur J Med Chem. 2023 Jul 28;260:115690.