CNBCA
CNBCA is a potent, selective, competitive SHP2 enzyme inhibitor, with the IC50 of 0.87 μM. CNBCA binds to full-length SHP2 and inhibits enzyme activity. CNBCA inhibits pAkt and pERK1/2, and the cell growth of BT474 and MDA-MB468 cells. CNBCA can be used for breast cancer study[1].
Product Specifications
UNSPSC
12352005
Target
SHP2
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cnbca.html
Solubility
10 mM in DMSO
Smiles
OC(CCCC1=C(OCCCCCCCCC)C=CC(C2=CC=C(C(O)=O)C=C2)=C1)=O
Molecular Formula
C26H34O5
Molecular Weight
426.55
References & Citations
[1]Dhanaji M, et al. Targeting SHP2 with an Active Site Inhibitor Blocks Signaling and Breast Cancer Cell Phenotypes. ACS Bio Med Chem Au 2023
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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