ATM Inhibitor-9

ATM Inhibitor-9 (Compd 7a) is a potent ATM inhibitor with IC505 nM for ATM kinase, useful in cancer research[1].

Product Specifications

CAS Number

[2951007-81-9]

UNSPSC

12352005

Target

ATM/ATR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/atm-inhibitor-9.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=NC2=CC(C3=CC=C(N=C3)OCCCN(C)C)=CC=C2N=C1)NC4CCCCC4

Molecular Formula

C25H32N6O2

Molecular Weight

448.56

References & Citations

[1]Dexin Deng, et al. Discovery and Evaluation of 3-Quinoxalin Urea Derivatives as Potent, Selective, and Orally Available ATM Inhibitors Combined with Chemotherapy for the Treatment of Cancer via Goal-Oriented Molecule Generation and Virtual Screening. J Med Chem. 2023 Jul 27;66 (14) :9495-9518.