ATM Inhibitor-8
ATM Inhibitor-8 (Compound 10r) is a highly potent, selective and orally active ATM inhibitor, with an IC50 of 1.15 nM. ATM Inhibitor-8 exhibits anti-tumor activity[1].
Product Specifications
CAS Number
2956666-60-5
UNSPSC
12352005
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atm-inhibitor-8.html
Solubility
10 mM in DMSO
Smiles
CN(C1=NC2=CC(C3=CN=C(C=C3)OCCCN4CCCCC4)=CC=C2N=C1)C(NC(C)C)=O
Molecular Formula
C26H34N6O2
Molecular Weight
462.59
References & Citations
[1]D Deng, et al. Discovery and Evaluation of 3-Quinoxalin Urea Derivatives as Potent, Selective, and Orally Available ATM Inhibitors Combined with Chemotherapy for the Treatment of Cancer via Goal-Oriented Molecule Generation and Virtual Screening. J Med Chem. 2023 Jul 27
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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