HAChE-IN-4

HAChE-IN-4 (Compd 5d) is a potent, blood-brain barrier-permeable hAChE inhibitor with IC50 of 0.25 μM. hAChE-IN-4 can be used in Alzheimer's disease research[1].

Product Specifications

CAS Number

[2983723-58-4]

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hache-in-4.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(Cl)C=C1)COC2=CC3=C(C=C2)C(C4=CC=C(Cl)C(Cl)=C4)C5=C(N)C6=C(N=C5O3)CCCC6

Molecular Formula

C30H23Cl3N2O3

Molecular Weight

565.87

References & Citations

[1]Salma Fares, et al. Modified Tacrine Derivatives as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Synthesis, Biological Evaluation, and Molecular Modeling Study. ACS Omega. 2023 Jul 12;8 (29) :26012-26034.