TRAP1-IN-1
TRAP1-IN-1 (compound 35) is a potent and selective inhibitor of TRAP1, a mitochondrial isoform of Hsp90. TRAP1-IN-1 has >250-fold TRAP1 selectivity over Grp94, and disrupts TRAP1 tetramer stability, induces TRAP1 client protein degradation. TRAP1-IN-1 also inhibits mitochondrial complex I of oxidative phosphorylation OXPHOS, disrupts the mitochondrial membrane potential, and enhances glycolysis metabolism[1].
Product Specifications
CAS Number
[3031102-94-7]
UNSPSC
12352005
Target
HSP; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trap1-in-1.html
Purity
96.03
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(C1=C(O)C=CC(C(N2CC(C(F)=CC=C3)=C3C2)=O)=C1)N(C4)CC5=C4C=CC(OCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)=C5.F[P-](F)(F)(F)(F)F
Molecular Formula
C45H39F7N2O4P2
Molecular Weight
866.74
References & Citations
[1]Merfeld T, et al. Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes. Eur J Med Chem. 2023 Oct 5;258:115531.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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