IR-251

IR-251 is a mitochondrion-targeting NIR fluorescent probe. IR-251 targets mitochondria via OATPs and causes mitochondrial damage in tumor cells. IR-251 IR-251 induced ROS overproduction by inhibiting PPARγ, and then inhibiting the β-catenin signaling pathway and downstream protein molecules related to the cell cycle and metastasis. IR-251 inhibits tumor proliferation and metastasis[1].

Product Specifications

UNSPSC

12171500

Target

Fluorescent Dye; Mitochondrial Metabolism; PPAR; Reactive Oxygen Species (ROS) ; β-catenin

Type

Dye Reagents

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ir-251.html

Solubility

10 mM in DMSO

Smiles

CC1(C)C(/C=C/C2=C(Cl)/C(CCC2)=C/CC3N(CCCCCC(O/C(NC4CCCCC4)=N/C5CCCCC5)=O)C(C=CC=C6)=C6C3(C)C)=[N+](CC)C7=C1C=CC=C7.[Br-]

Molecular Formula

C51H70BrClN4O2

Molecular Weight

886.48

References & Citations

[1]Wang J, et al. A novel multifunctional mitochondrion-targeting NIR fluorophore probe inhibits tumour proliferation and metastasis through the PPAR/ROS/-catenin pathway. Eur J Med Chem. 2023 Oct 5;258:115435.