Antibacterial agent 144

Antibacterial agent 144 (compound 8e) is an antibacterial agent, with better effect against multi-resistant Staphylococcus aureus than Chloromycin and Amoxicillin (HY-B0467A) . Antibacterial agent 144 destroys the cytoplasmic membrane of bacteria, and inhibits the biofilms formation. Antibacterial agent 144 binds to HSA (Kd=13.2 μM), and exerts bactericidal efficacy. Antibacterial agent 144 also binds with DNA to for supramolecular complex to obstruct DNA replications[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

Bacterial; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antibacterial-agent-144.html

Solubility

10 mM in DMSO

Smiles

O=C(N(NC1=NC(NCC2=CC=CC=C2)=NC(N3CCOCC3)=N1)C4=O)C5=C(C4=CC=C6)C6=CC=C5

Molecular Formula

C26H23N7O3

Molecular Weight

481.51

References & Citations

[1]Gupta S, et al. Membrane-active substituted triazines as antibacterial agents against Staphylococcus aureus with potential for low drug resistance and broad activity. Eur J Med Chem. 2023 Oct 5;258:115551.