BDM91514

BDM91514 improves antibiotic potency through AcrB inhibition. BDM91514 prevents the growth of E. coliBW25113 (EC90: 8 μM) in the presence of 8 μg/mL Pyridomycin. BDM91514 has suitable plasma and microsomal stability[1].

Product Specifications

CAS Number

[2892824-90-5]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/bdm91514.html

Solubility

10 mM in DMSO

Smiles

ClC1=C(N2CCNCC2)N=CC(C3=NOC(CCN)=N3)=C1.Cl.Cl

Molecular Formula

C13H19Cl3N6O

Molecular Weight

381.69

References & Citations

[1]Compagne N, et al. Optimization of pyridylpiperazine-based inhibitors of the Escherichia coli AcrAB-TolC efflux pump. Eur J Med Chem. 2023 Jul 7;259:115630.