Antitumor agent-104
Antitumor agent-104 (Compound 9) is an antitumor agent by inhibiting DNA damage repair in tumors. Antitumor agent-104 inhibits PARP1 enzymatic activity and the PAR protein level. Antitumor agent-104 also inhibits the expression of CDK12[1].
Product Specifications
CAS Number
2245272-16-4
UNSPSC
12352005
Target
CDK; PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-104.html
Solubility
10 mM in DMSO
Smiles
O=C1NN=C(CC2=CC=C(F)C(C(N3CCC(N=C(OCCCN4CCCCC4)N=C5)=C5C3)=O)=C2)C6=CC=CC=C61
Molecular Formula
C31H33FN6O3
Molecular Weight
556.63
References & Citations
[1]Lin S, et al. Synthesis of Novel Dual Target Inhibitors of CDK12 and PARP1 and Their Antitumor Activities in HER2-Positive Breast Cancers. ACS Omega. 2023 Jul 7;8 (28) :25574-25581.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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