Antitumor agent-104

Antitumor agent-104 (Compound 9) is an antitumor agent by inhibiting DNA damage repair in tumors. Antitumor agent-104 inhibits PARP1 enzymatic activity and the PAR protein level. Antitumor agent-104 also inhibits the expression of CDK12[1].

Product Specifications

CAS Number

[2245272-16-4]

UNSPSC

12352005

Target

CDK; PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antitumor-agent-104.html

Solubility

10 mM in DMSO

Smiles

O=C1NN=C(CC2=CC=C(F)C(C(N3CCC(N=C(OCCCN4CCCCC4)N=C5)=C5C3)=O)=C2)C6=CC=CC=C61

Molecular Formula

C31H33FN6O3

Molecular Weight

556.63

References & Citations

[1]Lin S, et al. Synthesis of Novel Dual Target Inhibitors of CDK12 and PARP1 and Their Antitumor Activities in HER2-Positive Breast Cancers. ACS Omega. 2023 Jul 7;8 (28) :25574-25581.