P-gp inhibitor 15
P-gp inhibitor 15 (compound 7a) is a nonsubstrate inhibitor of P-glycoprotein (Pgp). P-gp inhibitor 15 inhibits Pgp-ATPase activity, and interfers Pgp-mediated Rhodamine123 efflux. P-gp inhibitor 15 also enhances the inhibitory efficacy of Paclitaxel , inhibits tumor progress in nude mice KBV xenograft tumors model[1].
Product Specifications
CAS Number
2303508-09-8
UNSPSC
12352005
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p-gp-inhibitor-15.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@](C([C@H](CC1)NC([C@@H]3CCCN3)=O)(C)C)(CC[C@]4(C)[C@]2([H])C[C@@H](O)[C@@]5([H])[C@@]4(C)CC[C@@H]5[C@]6(C)CC[C@H](C(C)(C)O)O6)[H]
Molecular Formula
C35H60N2O4
Molecular Weight
572.86
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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