SEH inhibitor-16
SEH inhibitor-16 is a soluble epoxide hydrolase (sEH) inhibitors with an IC50 of 2 nM. sEH inhibitor-16 reduces the inflammatory damage in Cerulein (HY-A0190) -induced acute pancreatitis (AP) in mice and can be used for inflammation/immunology research[1].
Product Specifications
CAS Number
[2999636-75-6]
UNSPSC
12352005
Target
Epoxide Hydrolase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/seh-inhibitor-16.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC2=C(N(CC3=CC=C(C(C)C)C=C3)C=C2)C=C1)NCC4(C5)C[C@H](C[C@H]5C6)C[C@H]6C4
Molecular Formula
C30H37N3O
Molecular Weight
455.63
References & Citations
[1]Musella S, et.al. Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis. J Med Chem. 2023 Jul 13;66 (13) :9201-9222.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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