Anticancer agent 127
Anticancer agent 127 (142D6) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 127 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC50s of 12 nM, 14 nM, and 9 nM, respectively. Anticancer agent 127 has anticancer effects[1].
Product Specifications
CAS Number
[2410953-19-2]
UNSPSC
12352005
Target
IAP
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-127.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@H](C(N[C@H]2C(C=CC=C3OS(=O)(F)=O)=C3CC2)=O)CCC1)[C@H](C4CCCCC4)NC([C@H](C)NC)=O
Molecular Formula
C26H37FN4O6S
Molecular Weight
552.66
References & Citations
[1]Udompholkul P, et al. Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist. J Med Chem. 2023 Jun 22;66 (12) :8159-8169.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6502582-01 0.2 mL
TRIP13, NT (Thyroid Receptor-interacting Protein 13, Thyroid Hormone Receptor Interactor 13, TR-interacting Protein 13, TRIP-13, Human Papillomavirus Type 16 E1 Protein-binding Protein, HPV16 E1 Protein-binding Protein, 16E1-BP) (FITC)
Ask
View Details MBS6502582-02 5x 0.2 mL
TRIP13, NT (Thyroid Receptor-interacting Protein 13, Thyroid Hormone Receptor Interactor 13, TR-interacting Protein 13, TRIP-13, Human Papillomavirus Type 16 E1 Protein-binding Protein, HPV16 E1 Protein-binding Protein, 16E1-BP) (FITC)
Ask
View Details