PHD2-IN-1

PHD2-IN-1 is a potent and orally active inhibitor of HIF prolyl hydroxylase 2 (PHD2) with an IC50 of 22.53 nM. PHD2-IN-1 can be used for anemia research[1].

Product Specifications

CAS Number

[2768219-28-7]

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/phd2-in-1.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(NCC(N2CCC(C3=CN=C(C(NCC(O)=O)=O)C(O)=C3)CC2)=O)C=C1

Molecular Formula

C21H23ClN4O5

Molecular Weight

446.88

References & Citations

[1]Wu Y, et.al. Preferred Conformation-Guided Discovery of Potent and Orally Active HIF Prolyl Hydroxylase 2 Inhibitors for the Treatment of Anemia. J Med Chem. 2023 Jul 13;66 (13) :8545-8563.