Ara-SH

Ara-SH is a Cytarabine mercaptopropionic acid-substituted derivative. Ara-SH is used as the trigger to fabricate a smart Cytarabine and Venetoclax-coloaded nanoparticle (AV-NP) through self-assembly. Ara-SH exhibits remarkable synergistic antileukemia effects in vitro and in vivo[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ara-sh.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=NC(N([C@@H]2O[C@@H]([C@H]([C@@H]2O)O)CO)C=C1)=O)CCS

Molecular Formula

C12H17N3O6S

Molecular Weight

331.34

References & Citations

[1]Lejiao Jia, et al. Smart and Generalizable Cytarabine Derivative-Triggered Nanoparticles for Synergistic Therapy of Relapsed/Refractory Acute Myeloid Leukemia. ACS Appl Mater Interfaces. 2023 Jun 14;15 (23) :27624-27637.