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RSV L-protein-IN-5

Selected Variant

HY-154968

Size: 1 Each

RSV L-protein-IN-5 (compound E) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC50=0.1 μM) . RSV L-protein-IN-5 inhibits Polymerase (IC50=0.66 μM), and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-5 shows moderate cytotoxicity (CC50=10.7 μM, HEp-2), also exhibits activity and lowers virus titers in mouse models of RSV infection[1].

Product Specifications

CAS Number

851658-28-1

UNSPSC

12352005

Target

RSV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/rsv-l-protein-in-5.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(C(C)(C)C(N1CCCNCCC3=CC=C(C(OC)=C3)OC)=O)C=C(N)C4=C2NC(C5=CC=CC(C)=N5)=N4

Molecular Formula

C31H36N6O4

Molecular Weight

556.66

References & Citations

[1]Liuzzi M, et al. Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase. J Virol. 2005 Oct;79 (20) :13105-15.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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