MTOR inhibitor-11
MTOR inhibitor-11 (Compound 9) is a brain-penetrant mTOR inhibitor (IC50: 21 nM for pS6) . mTOR inhibitor-11 also inhibits pCHK1 and PDE4D with IC50s of 17.2 and 17.0 μM. mTOR inhibitor-11 can be used for research of CNS disease[1].
Product Specifications
CAS Number
3033409-32-1
UNSPSC
12352005
Target
MTOR
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mtor-inhibitor-11.html
Solubility
10 mM in DMSO
Smiles
C[C@@H]1COCCN1C2=C3N=C(C4=NC=CC=C4)NC3=NC(N5[C@@H](C)COCC5)=C2
Molecular Formula
C21H26N6O2
Molecular Weight
394.47
References & Citations
[1]Bonazzi S, et al. Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes. J Med Chem. 2023 Jul 13;66 (13) :9095-9119.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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