PD-1/PD-L1-IN-34

PD-1/PD-L1-IN-34 (Compound (1S,2S) -A25) inhibits PD-1/PD-L1 interaction (IC50=0.029 μM), with a selected binding affinity with PD-L1 (KD=0.1554 μM) . PD-1/PD-L1-IN-34 inhibits tumor growth by activating the immune microenvironment[1].

Product Specifications

CAS Number

[2924403-17-6]

UNSPSC

12352005

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pd-1-pd-l1-in-34.html

Solubility

10 mM in DMSO

Smiles

CC1=C([C@@H]2[C@@H](C3=CC(OCC4=CC=CC(C#N)=C4)=C(C=C3Cl)CNC(C)(C(O)=O)C)C2)C=CC=C1C5=CC=CC=C5

Molecular Formula

C35H33ClN2O3

Molecular Weight

565.10

References & Citations

[1]Jing T, et al. Discovery and Optimization of Novel Biphenyl Derivatives Bearing Cyclopropyl Linkage as Potent Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Inhibitors. J Med Chem. 2023 May 25;66 (10) :6811-6835.