1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine

1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine is a glycerophosphorylcholine, consisting of glycerol phosphate, choline and palmitic acid. It accumulates in vivo at sites of oxidative stress. 1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine may be a ligand of scavenger receptors class B, while oxidized phospholipids oxPC (CD36) are potent ligands of scavenger receptors class B (CD36 and SR-BI) . Oxidized phospholipids (oxPLs) also play an important role in tumor apoptosis, may be elevated in malignant biliary strictures[1][2].

Product Specifications

CAS Number

[89947-80-8]

UNSPSC

12352211

Target

Scavenger Receptor Class B type I (SR-BI)

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-palmitoyl-2-succinyl-sn-glycerophosphorylcholine.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

C[N+](C)(C)CCOP(OC[C@H](OC(CCC(O)=O)=O)COC(CCCCCCCCCCCCCCC)=O)([O-])=O

Molecular Formula

C28H54NO10P

Molecular Weight

595.70

References & Citations

[1]Navaneethan U, et al Lipidomic profiling of bile in distinguishing benign from malignant biliary strictures: a single-blinded pilot study. Am J Gastroenterol. 2014 Jun;109 (6) :895-902. |[2]Gao D, et al. Structural basis for the recognition of oxidized phospholipids in oxidized low density lipoproteins by class B scavenger receptors CD36 and SR-BI. J Biol Chem. 2010 Feb 12;285 (7) :4447-54.