HDAC-IN-56

HDAC-IN-56 ((S) -17b) is an orally active class I histone deacetylase (HDAC) inhibitor with IC50 values of 56.0 ± 6.0, 90.0 ± 5.9, 422.2 ± 105.1, >10000 nM for HDAC1, HDAC2, HDAC3, and HDAC4-11, respectively. HDAC-IN-56 has potent inhibitory activity while strongly increasing intracellular levels of acetylhistone H3 and P21 and effectively inducing G1 cell cycle arrest and apoptosis.HDAC-IN-56 has antitumor activity [1].

Product Specifications

CAS Number

[2814571-89-4]

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac-in-56.html

Solubility

10 mM in DMSO

Smiles

O=C1C=CC(C2=CC=C(C=C2)CN(C)C)=NN1[C@H](C3=CC=C(C=C3)C(NC4=C(N)C=C(C=C4)F)=O)C

Molecular Formula

C28H28FN5O2

Molecular Weight

485.55

References & Citations

[1]Li D, et al. Discovery of (S) -N- (2-Amino-4-fluorophenyl) -4- (1- (3- (4- ((dimethylamino) methyl) phenyl) -6-oxopyridazin-1 (6H) -yl) ethyl) benzamide as Potent Class I Selective HDAC Inhibitor for Oral Anticancer Drug Candidate. J Med Chem. 2023 May 25;66 (10) :7016-7037.