BBDDL2059
Product Specifications
UNSPSC Description
BBDDL2059 is a selective covalent inhibitor of histone methyltransferase EZH2 with an IC50 of 1.5 nM for EZH2-Y641F. BBDDL2059 inhibits lymphoma cell growth at nanomolar concentrations and can be used for anticancer research[1].
Target Antigen
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bbddl2059.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(CNC(C=C)=O)=CC(N(C2CCOCC2)CC)=C1C)NCC3=C(C=C(NC3=O)C)SC
Molecular Weight
512.66
References & Citations
[1]Zhang Y, et.al. Discovery of a New-Generation S-Adenosylmethionine-Noncompetitive Covalent Inhibitor Targeting the Lysine Methyltransferase Enhancer of Zeste Homologue 2. J Med Chem. 2023 Jun 8;66(11):7629-7644.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-154854/BBDDL2059-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-154854/
Clinical Information
No Development Reported
CAS Number
2691174-27-1
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