BBDDL2059
BBDDL2059 is a selective covalent inhibitor of histone methyltransferase EZH2 with an IC50 of 1.5 nM for EZH2-Y641F. BBDDL2059 inhibits lymphoma cell growth at nanomolar concentrations and can be used for anticancer research[1].
Product Specifications
CAS Number
[2691174-27-1]
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bbddl2059.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(CNC(C=C)=O)=CC(N(C2CCOCC2)CC)=C1C)NCC3=C(C=C(NC3=O)C)SC
Molecular Formula
C27H36N4O4S
Molecular Weight
512.66
References & Citations
[1]Zhang Y, et.al. Discovery of a New-Generation S-Adenosylmethionine-Noncompetitive Covalent Inhibitor Targeting the Lysine Methyltransferase Enhancer of Zeste Homologue 2. J Med Chem. 2023 Jun 8;66 (11) :7629-7644.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EZH2
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1095887-01 0.02 mg (E-Coli)
Recombinant Escherichia coli CS6 fimbrial subunit A (cssA)
Ask
View Details 
MBS1095887-02 0.1 mg (E-Coli)
Recombinant Escherichia coli CS6 fimbrial subunit A (cssA)
Ask
View Details 
MBS1095887-03 0.02 mg (Yeast)
Recombinant Escherichia coli CS6 fimbrial subunit A (cssA)
Ask
View Details MBS1095887-04 0.1 mg (Yeast)
Recombinant Escherichia coli CS6 fimbrial subunit A (cssA)
Ask
View Details 
MBS1095887-05 0.02 mg (Baculovirus)
Recombinant Escherichia coli CS6 fimbrial subunit A (cssA)
Ask
View Details