Cav 3.2 inhibitor 4
Cav 3.2 inhibitor 4 (compound 21) is a potent, peripherally restricted, selective T-type calcium channel (Cav3.2) inhibitor, with an IC50 of 0.6 μM. Cav 3.2 inhibitor 4 can be used for the research of atrial fibrillation[1].
Product Specifications
CAS Number
1416984-93-4
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cav-3-2-inhibitor-4.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1(CO)CCN(CCNC(NC(C)(C)C)=O)CC1)C2=CC(Cl)=CC(Cl)=C2
Molecular Formula
C21H32Cl2N4O3
Molecular Weight
459.41
References & Citations
[1]Giordanetto F, et, al. Discovery of N-[[1-[2- (tert-butylcarbamoylamino) ethyl]-4- (hydroxymethyl) -4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor. Bioorg Med Chem Lett. 2013 Jan 1;23 (1) :119-24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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