4’-Azido-3’-O-benzoyl-5’-O- (m-chlorobenzoyl) -2’-deoxy-2’-fluoro-beta-D-arabinouridine
Selected Variant
HY-154678
Size: 1 Each
4’-Azido-3’-O-benzoyl-5’-O- (m-chlorobenzoyl) -2’-deoxy-2’-fluoro-beta-D-arabinouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 4’-Azido-3’-O-benzoyl-5’-O- (m-chlorobenzoyl) -2’-deoxy-2’-fluoro-beta-D-arabinouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Product Specifications
CAS Number
1333126-30-9
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4-azido-3-o-benzoyl-5-o-m-chlorobenzoyl-2-deoxy-2-fluoro-beta-d-arabinouridine.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC(Cl)=C1)OC[C@]2(N=[N+]=[N-])[C@@H](OC(C3=CC=CC=C3)=O)[C@H](F)[C@H](N4C(NC(C=C4)=O)=O)O2
Molecular Formula
C23H17ClFN5O7
Molecular Weight
529.86
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Price
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