6-S- (2-Cyanoethyl) -2’-deoxy-5’-O-DMTr--6-thioguanosine 3’-CED phosphoramidite
Selected Variant
HY-154617
Size: 1 Each
6-S- (2-Cyanoethyl) -2’-deoxy-5’-O-DMTr--6-thioguanosine 3’-CED phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/6-s-2-cyanoethyl-2-deoxy-5-o-dmtr-6-thioguanosine-3-ced-phosphoramidite.html
Solubility
10 mM in DMSO
Smiles
NC(N=C1SCCC#N)=NC2=C1N=CN2[C@@H]3O[C@H](COC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)C3
Molecular Formula
C43H51N8O6PS
Molecular Weight
838.95
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Price
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