2’-dG (iBu) -2’-phosphoramidite
2’-dG (iBu) -2’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
CAS Number
[157327-97-4]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2-dg-ibu-2-phosphoramidite.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(NC(C(C)C)=O)=NC2=C1N=CN2[C@@H]3O[C@H](COC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C[C@H]3OP(OCCC#N)C(C(C)C)C(C)C
Molecular Formula
C45H55N6O8P
Molecular Weight
838.93
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
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