(Rac) -Tezacaftor
(Rac) -Tezacaftor ((Rac) -VX-661) is a racemate of Tezacaftor (HY-15448) . Tezacaftor is a F508del CFTR corrector. (Rac) -Tezacaftor can be used for the research of cystic fibrosis[1].
Product Specifications
CAS Number
[1226709-85-8]
Product Name Alternative
(Rac) -VX-661
UNSPSC
12352005
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rac-tezacaftor.html
Purity
96.30
Solubility
10 mM in DMSO
Smiles
FC1=C(NC(C2(CC2)C3=CC4=C(OC(F)(F)O4)C=C3)=O)C=C(C=C5C(C)(C)CO)C(N5CC(O)CO)=C1
Molecular Formula
C26H27F3N2O6
Molecular Weight
520.50
References & Citations
[1]Keating D, et al. VX-445-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles. N Engl J Med. 2018 Oct 25;379 (17) :1612-1620.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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