N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite
N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) [1].
Product Specifications
UNSPSC
12352005
Hazard Statement
H315-H319
Target
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n2-ibu-5-o-dmtr-2-o-propargylguanosine-3-ced-phosphoramidite.html
Solubility
10 mM in DMSO
Smiles
C#CCO[C@@H]1[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](COC(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)O[C@H]1N5C=NC6=C5N=C(NC(C(C)C)=O)NC6=O
Molecular Formula
C47H56N7O9P
Molecular Weight
893.96
Precautions
P264-P280-P302+P352-P305+P351+P338-P362+P364
References & Citations
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-154351/N2-iBu-5-O-DMTr-2-O-propargylguanosine-3-CED-phosphoramidite-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-154351/
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
CAS Number
[171486-61-6]
Available Sizes
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