N1-Ethyl-2’-O-TBDMS-5’-O-DMTr-3’-phosphoramidite
N1-Ethyl-2’-O-TBDMS-5’-O-DMTr-3’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n1-ethyl-2-o-tbdms-5-o-dmtr-3-phosphoramidite.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=O)N(CC)C=C1[C@@H]2O[C@H](COC(C3=CC=CC=C3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)[C@@H](OP(N(C(C)C)C(C)C)OCC[N+]#[C-])[C@H]2O[Si](C)(C)C(C)(C)C
Molecular Formula
C47H65N4O9PSi
Molecular Weight
889.10
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Frequently Asked Questions
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