TLR7 agonist 12
Product Specifications
UNSPSC Description
TLR7 agonist 12 (example 20) is a TLR7 agonist, also is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1][2].
Target Antigen
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tlr7-agonist-12.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]1[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N(CCCC(O)=O)C2=O)O[C@@H]1CO
Molecular Weight
385.33
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.|[2]Webber, et al. TLR7 agonists for treatment of cancer and infectious disease. World Intellectual Property Organization, WO2019226977 A1. 2019-11-28.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-154271/TLR7-agonist-12-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-154271/
Clinical Information
No Development Reported
CAS Number
2389988-47-8
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
