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TLR7 agonist 12

TLR7 agonist 12 (example 20) is a TLR7 agonist, also is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1][2].

Product Specifications

CAS Number

[2389988-47-8]

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tlr7-agonist-12.html

Solubility

10 mM in DMSO

Smiles

O[C@@H]1[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N(CCCC(O)=O)C2=O)O[C@@H]1CO

Molecular Formula

C14H19N5O8

Molecular Weight

385.33

References & Citations

[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.|[2]Webber, et al. TLR7 agonists for treatment of cancer and infectious disease. World Intellectual Property Organization, WO2019226977 A1. 2019-11-28.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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