TLR7 agonist 12
TLR7 agonist 12 (example 20) is a TLR7 agonist, also is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1][2].
Product Specifications
CAS Number
[2389988-47-8]
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tlr7-agonist-12.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]1[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N(CCCC(O)=O)C2=O)O[C@@H]1CO
Molecular Formula
C14H19N5O8
Molecular Weight
385.33
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.|[2]Webber, et al. TLR7 agonists for treatment of cancer and infectious disease. World Intellectual Property Organization, WO2019226977 A1. 2019-11-28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6503800-01 0.1 mL
Troponin I, Cardiac, aa69-86 (cTnI, CMH7, Familial Hypertrophic Cardiomyopathy 7, MGC116817, TNNC1, Troponin I Type 3 Cardiac, TNNI3) (HRP)
Ask
View Details 
MBS6503800-02 5x 0.1 mL
Troponin I, Cardiac, aa69-86 (cTnI, CMH7, Familial Hypertrophic Cardiomyopathy 7, MGC116817, TNNC1, Troponin I Type 3 Cardiac, TNNI3) (HRP)
Ask
View Details I8439-10A-HRP 100 µL
Interleukin 17 (IL-17, CTLA8, IL-17A, Interleukin-17A precursor, Cytotoxic T-lymphocyte-associated antigen 8) (HRP) discontinued
Ask
View Details MBS1083460-01 0.02 mg (E-Coli)
Recombinant Zea mays Glutamine synthetase, chloroplastic (GLN2)
Ask
View Details MBS1083460-02 0.02 mg (Yeast)
Recombinant Zea mays Glutamine synthetase, chloroplastic (GLN2)
Ask
View Details