5'-O-DMT-2-thio-2'-dU-3'-phosphoramidite
Product Specifications
UNSPSC Description
5'-O-DMT-2-thio-2'-dU-3'-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Target Antigen
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5-o-dmt-2-thio-2-du-3-phosphoramidite.html
Solubility
10 mM in DMSO
Smiles
CC(C)N(C(C)C)P(OCCC#N)O[C@H]1C[C@H](N2C(NC(C=C2)=O)=S)O[C@@H]1COC(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5
Molecular Weight
746.85
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-154267/5-O-DMT-2-thio-2-dU-3-phosphoramidite-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-154267/
Clinical Information
No Development Reported
CAS Number
152753-94-1
Curated Selection
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