5’-O-TBDPS-2,2’-anhydrouridine
5’-O-TBDPS-2,2’-anhydrouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
CAS Number
[175013-46-4]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5-o-tbdps-2-2-anhydrouridine.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@@](OC(N2C=C3)=NC3=O)([H])[C@@]2([H])O[C@@H]1CO[Si](C4=CC=CC=C4)(C5=CC=CC=C5)C(C)(C)C
Molecular Formula
C25H28N2O5Si
Molecular Weight
464.59
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
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