Edonentan (hydrate)
Edonentan (BMS 207940) hydrate is a potent and selective antagonist of the endothelin A (ETA) receptor, with a Ki of 10 pM. In rats, Edonentan has superior (100%) oral bioavailbility[1].
Product Specifications
CAS Number
264609-13-4
Product Name Alternative
BMS 207940 (hydrate)
UNSPSC
12352005
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/edonentan-hydrate.html
Solubility
10 mM in DMSO
Smiles
CC(C)(C)CC(N(CC1=CC(C2=NC=CO2)=CC=C1C3=CC=CC=C3S(=O)(NC4=NOC(C)=C4C)=O)C)=O.O
Molecular Formula
C28H34N4O6S
Molecular Weight
554.66
References & Citations
[1]Murugesan N, et al. Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[ (4,5-dimethyl-3-isoxazolyl) amino]sulfonyl]-4- (2-oxazolyl) [1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET (A) selective antagonist. J Med Chem. 2003 Jan 2;46 (1) :125-37.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
ETA
Frequently Asked Questions
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