5-Fluoromethylornithine (dihydrochloride)

5-Fluoromethylornithine (5-FMOrn) dihydrochloride is a specific irreversible inhibitor of L-ornithine:2-oxoacid aminotransferase (OAT) . 5-Fluoromethylornithine dihydrochloride can be used in the study of gyrate atrophy of choroid and retina[1][2].

Product Specifications

CAS Number

[124796-41-4]

Product Name Alternative

5-FMOrn (dihydrochloride)

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

OAT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/5-fluoromethylornithine-dihydrochloride.html

Concentration

10mM

Purity

99.08

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)

Smiles

NC(CCC(N)CF)C(O)=O.[H]Cl.[H]Cl

Molecular Formula

C6H15Cl2FN2O2

Molecular Weight

237.10

Precautions

H315, H319, H335

References & Citations

[1]Daune G, et al. 5-Fluoromethylornithine, an irreversible and specific inhibitor of L-ornithine:2-oxo-acid aminotransferase. Biochem J. 1988 Jul 15;253 (2) :481-8. |[2]Nakauchi T, et al. Prevention of ornithine cytotoxicity by nonpolar side chain amino acids in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2003 Nov;44 (11) :5023-8.