PPARγ agonist 8

PPARγ agonist 8 is an agonist of PPARγ. PPARγ agonist 8 induces peroxisome proliferator response element (PPRE) -luciferase activity with an EC50 of 0.2 μM[1].

Product Specifications

CAS Number

[1049800-41-0]

UNSPSC

12352005

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pparγ-agonist-8.html

Solubility

10 mM in DMSO

Smiles

OC(CC1=C/C(C2=CC=C(F)C=C21)=C\C3=CC=C(C=C3)SC(F)(F)F)=O

Molecular Formula

C19H12F4O2S

Molecular Weight

380.36

References & Citations

[1]Felts AS, et.al. Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition. J Med Chem. 2008 Aug 28;51 (16) :4911-9.