WRN inhibitor 2
WRN inhibitor 2 (example 118) is a WRN (Werner Syndrome ATP dependent helicase enzyme) inhibitor, with pIC50 ≥ 7.0[1].
Product Specifications
CAS Number
[2923009-56-5]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wrn-inhibitor-2.html
Purity
99.60
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C(NC(C(C(N[C@@H]2C=CS(=O)(C2)=O)=O)=C1)=O)C3=CSC(C(F)(F)F)=C3
Molecular Formula
C15H11F3N2O5S2
Molecular Weight
420.38
References & Citations
[1]Ashley ADAMS, et al. Cyclic vinyl sulfone compounds as wrn inhibitors. Patent, WO2023062575A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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