URAT1 inhibitor 7
URAT1 inhibitor 7 (compound 10f) is a potent URAT1 inhibitor, with an IC50 of 12 nM. URAT1 inhibitor 7 exhibits microsomal stability (HLM CYP2C9, with an IC50 of 4.2 μM. URAT1 inhibitor 7 can be used for gout research[1].
Product Specifications
CAS Number
1632002-28-8
UNSPSC
12352005
Target
URAT1
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/urat1-inhibitor-7.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC=C(C=C1Cl)OC2=CC=C(S(=O)(NC3=NC=C(C=C3)F)=O)C=C2C#N
Molecular Formula
C19H10ClFN4O3S
Molecular Weight
428.82
References & Citations
[1]Storer R I, et al. The discovery and evaluation of diaryl ether heterocyclic sulfonamides as URAT1 inhibitors for the treatment of gout. MedChemComm, 2016:10.1039.C6MD00190D.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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