Bcl-2-IN-11
Product Specifications
UNSPSC Description
Bcl-2-IN-11 (compound 6) is a potent and selective Bcl-2 activity inhibitor, with an IC50 of 0.9 nM. Bcl-2-IN-11 shows weak inhibition of Bcl-xl (IC50 > 1000 nM). Bcl-2-IN-11 can be used for the research of a variety of cancers caused by abnormal overexpression of Bcl-2 family proteins: especially malignant hematologic diseases of acute lymphoid leukemia, etc. Bcl-2-IN-11 can also avoid toxic side effects caused by Bcl-xl inhibition, such as thrombocytopenia[1].
Target Antigen
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcl-2-in-11.html
Solubility
10 mM in DMSO
Smiles
O=S(NC(C(C=CC(N1C[C@H](N(CC1)CC2=C(C3=CC=C(C=C3)Cl)CC(C)(CC2)C)C)=C4)=C4OC5=CN=C(NC=C6)C6=C5)=O)(C7=CC([N+]([O-])=O)=C(C(F)=C7)NC[C@H]8COCCO8)=O
Molecular Weight
902.43
References & Citations
[1]Kong Xianglong, et al. Heterocyclic compound as bcl-2 inhibitor. WO2022028353A1.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153953/Bcl-2-IN-11-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153953/
Clinical Information
No Development Reported
CAS Number
2760536-88-5
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
