Immuno modulator-1
Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM[1].
Product Specifications
CAS Number
2757469-20-6
UNSPSC
12352005
Target
Interleukin Related; Potassium Channel; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/immuno-modulator-1.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](N1CCN(C2=C(C=C(C=N2)C#N)F)CC1)C(C=C3)=CC=C3COC4=C5C(C(N([C@@H]6C(NC(CC6)=O)=O)C5)=O)=CC=C4
Molecular Formula
C32H31FN6O4
Molecular Weight
582.62
References & Citations
[1]Chen Xiangyang, et al. Heterocyclic immunomodulator. Patent, WO2022007659A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-2
Explore Other Products
Browse additional items from our catalog
Recombinant Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3)
Recombinant Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3)
Recombinant Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3)
Recombinant Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3)