CBP-IN-1
CBP-IN-1 (compound 12) is a potent CBP inhibitor, with an IC50 of 1.5 nM. CBP-IN-1 also inhibits CBP BRET and BRD4 (1), with IC50 values of 690 and 3100 nM, respectively[1].
Product Specifications
CAS Number
1936431-44-5
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbp-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C)N1CC2=C(CC1)N(C3CCNCC3)N=C2N4C5=C(CCC4)C=C(C6=CN(C)N=C6)C(C(F)F)=C5
Molecular Formula
C27H33F2N7O
Molecular Weight
509.59
References & Citations
[1]Romero FA, et al. GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) . J Med Chem. 2017 Nov 22;60 (22) :9162-9183.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
