BET-IN-15
BET-IN-15 (compound 1) is a potent and orally active BET inhibitor with IC50 values of 0.64, 0.25 nM for BRD4-BD1, BRD4-BD2, respectively. BET-IN-15 shows antiproliferative activity[1].
Product Specifications
CAS Number
2408994-22-7
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bet-in-15.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(C(C3=C(OC4=CC=C(C=C4F)F)C=CC(N=S(C)(C)=O)=N3)=CN1C)C=CN2
Molecular Formula
C21H18F2N4O3S
Molecular Weight
444.45
References & Citations
[1]WenWei Xu, et al. Crystal form and salt form of bromine domain protein inhibitor and preparation method therefor. WO2021143922A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
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