DG-8
DG-8 is a potent inhibitor of STAT3-dependent transcription (IC50 0.98 μM) . DG-8 is a fluorescent probe that contains a fluorescent dansyl moiety[1].
Product Specifications
UNSPSC
12171500
Target
Fluorescent Dye; STAT
Type
Dye Reagents
Related Pathways
JAK/STAT Signaling; Others; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/dg-8.html
Solubility
10 mM in DMSO
Smiles
O=C(N(CCN(C)S(C1=C(C=CC=C2N(C)C)C2=CC=C1)(=O)=O)C)C3=CC=C(N4C(C(Cl)=C(Cl)C=N4)=O)C=C3.Cl
Molecular Formula
C27H28Cl3N5O4S
Molecular Weight
624.97
References & Citations
[1]Busker S, et al. Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death. Sci Adv. 2020 Mar 20;6 (12) :eaax7945.
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Frequently Asked Questions
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