Magmas-IN-1

Magmas-IN-1 (compound 9) is a small molecule Magmas inhibitor (SMMI) . Magmas is mitochondria associated, granulocyte-macrophage colony stimulating factor signaling molecule, as well as a GM-CSF inducible gene in myeloid cells. Magmas-IN-1 inhibits Magmas and modulates mitochondrial function. Magmas-IN-1 also inhibits proliferation in yeast at 4 μM[1].

Product Specifications

CAS Number

[1251957-89-7]

UNSPSC

12352005

Hazard Statement

H302-H318-H410

Target

Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/magmas-in-1.html

Solubility

10 mM in DMSO

Smiles

CCC1=C(/C(CCC1(C)C)=C/C2=CC=C(C=C2)C(NC(N)=N)=O)C

Molecular Formula

C20H27N3O

Molecular Weight

325.45

Precautions

P264-P270-P273-P280-P305+P351+P338-P330-P391-P501

References & Citations

[1]Jubinsky PT, et al. Design, synthesis, and biological activity of novel Magmas inhibitors. Bioorg Med Chem Lett. 2011 Jun 1;21 (11) :3479-82.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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