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KRAS G12C degrader-1

KRAS G12C degrader-1 (Compound 283) is a potent KRAS G12C degrader (DC50: [1].

Product Specifications

CAS Number

[2768099-51-8]

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-kras-g12c-degrader-3.html

Solubility

10 mM in DMSO

Smiles

O=C(C=C)N1CCN(C2=NC(OC[C@H]3N(C)C[C@@H](N4CCN(C(C5CCN(CC6=CC=C(N7C(C(NCC)=O)=NN=C7C8=C(O)C=C(O)C(C(C)C)=C8)C=C6)CC5)=O)CC4)C3)=NC9=C2CCN(C%10=C(C(Cl)=CC=C%11)C%11=CC=C%10)C9)C[C@@H]1CC#N

Molecular Formula

C63H75ClN14O6

Molecular Weight

1159.81

References & Citations

[1]Methods and compositions for targeted protein degradation.WO2022078414.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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