KRAS G12C degrader-1
KRAS G12C degrader-1 (Compound 283) is a potent KRAS G12C degrader (DC50: [1].
Product Specifications
CAS Number
[2768099-51-8]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-kras-g12c-degrader-3.html
Solubility
10 mM in DMSO
Smiles
O=C(C=C)N1CCN(C2=NC(OC[C@H]3N(C)C[C@@H](N4CCN(C(C5CCN(CC6=CC=C(N7C(C(NCC)=O)=NN=C7C8=C(O)C=C(O)C(C(C)C)=C8)C=C6)CC5)=O)CC4)C3)=NC9=C2CCN(C%10=C(C(Cl)=CC=C%11)C%11=CC=C%10)C9)C[C@@H]1CC#N
Molecular Formula
C63H75ClN14O6
Molecular Weight
1159.81
References & Citations
[1]Methods and compositions for targeted protein degradation.WO2022078414.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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