KRAS G12C degrader-1
KRAS G12C degrader-1 (Compound 283) is a potent KRAS G12C degrader (DC50: [1].
Product Specifications
CAS Number
[2768099-51-8]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-kras-g12c-degrader-3.html
Solubility
10 mM in DMSO
Smiles
O=C(C=C)N1CCN(C2=NC(OC[C@H]3N(C)C[C@@H](N4CCN(C(C5CCN(CC6=CC=C(N7C(C(NCC)=O)=NN=C7C8=C(O)C=C(O)C(C(C)C)=C8)C=C6)CC5)=O)CC4)C3)=NC9=C2CCN(C%10=C(C(Cl)=CC=C%11)C%11=CC=C%10)C9)C[C@@H]1CC#N
Molecular Formula
C63H75ClN14O6
Molecular Weight
1159.81
References & Citations
[1]Methods and compositions for targeted protein degradation.WO2022078414.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Polyclonal FAM149A Antibody [DyLight 405]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
