KRAS degrader-1
KRAS degrader-1 (compound 1) is a potent KRAS degrader. KRAS degrader-1 target specific proteins for degradation through the autophagy-lysosomal degradation pathway[1].
Product Specifications
CAS Number
2795275-59-9
UNSPSC
12352005
Target
PROTACs; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-degrader-1.html
Solubility
10 mM in DMSO
Smiles
BrC(C=C(C=C1Br)/C=C2C3=CC(I)=CC=C3NC/2=O)=C1OCCOCCOCCOCCCN(CCC4)[C@@H]4COC5=NC(N6C[C@@H](N(CC6)C(C(F)=C)=O)CC#N)=C7C(CN(C8=CC=CC9=C8C(Cl)=CC=C9)CC7)=N5
Molecular Formula
C55H57Br2ClFIN8O7
Molecular Weight
1283.25
References & Citations
[1]Nan JI, et al. Methods and compounds for targeted autophagy. WO2022140246A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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