AST 7062601

AST 7062601 (AST070) is a Ucp1 inducer that strongly induces endogenous Ucp1 expression in primary mouse brown adipocytes. Ucp1 refers to uncoupling protein, found in brown and beige fat cells. In mammals, UCP1 oxidizes fatty acids and uncouples ATP production in mitochondria to promote energy dissipation as heat. AST 7062601 can be used to study thermogenic, uncoupled respiration[1].

Product Specifications

CAS Number

[675197-89-4]

Product Name Alternative

AST070

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Anion Exchangers

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ast-7062601.html

Solubility

10 mM in DMSO

Smiles

O=C1N=C(NC2=C1C=CC=C2)SCC(NC3=CC=C4OCCOC4=C3)=O

Molecular Formula

C18H15N3O4S

Molecular Weight

369.39

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Vergnes L, et al. Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation. J Biol Chem. 2020 Oct 30;295 (44) :15054-15069.