Z-NCTS
Z-NCTS is an RNA mismatch binding molecule that recognizes the 5’-r (XGG) -3’/5’-r (XGG) -3’ sequence (X=U or A) and acts as a molecular glue for RNA[1].
Product Specifications
CAS Number
1373391-77-5
UNSPSC
12352005
Target
Molecular Glues
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/z-ncts.html
Solubility
10 mM in DMSO
Smiles
CC1=NC2=C(C=C1)C=CC(NC(OCCCN(CCCOC(NC3=NC4=C(C=CC(C)=N4)C=C3)=O)CC(C=C5)=CC=C5/C=C\C(C=C6)=CC=C6CN(CCCOC(NC7=NC8=C(C=CC(C)=N8)C=C7)=O)CCCOC(NC9=NC%10=C(C=CC(C)=N%10)C=C9)=O)=O)=N2
Molecular Formula
C68H70N14O8
Molecular Weight
1211.37
References & Citations
[1]Chikara Dohno, et al. Molecular Glue for RNA: Regulating RNA Structure and Function through Synthetic RNA Binding Molecules. Chembiochem. 2019 Dec 2;20 (23) :2903-2910.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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