Antitumor agent-100
Antitumor agent-100 (compound A6) is an orally available apoptosis inducer and molecular gel targeting PDE3A-SLFN12 (IC50: 0.3 μM) with antitumor activity. Antitumor agent-100 binds to the PDE3A enzyme pocket to recruit and stabilize SLFN12, thereby preventing protein translation and leading to apoptosis[1].
Product Specifications
CAS Number
2841750-32-9
UNSPSC
12352005
Hazard Statement
H361-H373
Target
Apoptosis; Molecular Glues; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-100.html
Solubility
10 mM in DMSO
Smiles
O=C1N=C2NC3=C(CN2C1)C(Cl)=C(C4=CC=C(C)C=C4)C=C3
Molecular Formula
C17H14ClN3O
Molecular Weight
311.77
Precautions
P260-P280-P405-P501
References & Citations
[1]Jie Chen, et al. Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells. Nat Commun. 2021 Oct 27;12 (1) :6204.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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