Antitumor agent-100

Antitumor agent-100 (compound A6) is an orally available apoptosis inducer and molecular gel targeting PDE3A-SLFN12 (IC50: 0.3 μM) with antitumor activity. Antitumor agent-100 binds to the PDE3A enzyme pocket to recruit and stabilize SLFN12, thereby preventing protein translation and leading to apoptosis[1].

Product Specifications

CAS Number

[2841750-32-9]

UNSPSC

12352005

Hazard Statement

H361-H373

Target

Apoptosis; Molecular Glues; Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antitumor-agent-100.html

Solubility

10 mM in DMSO

Smiles

O=C1N=C2NC3=C(CN2C1)C(Cl)=C(C4=CC=C(C)C=C4)C=C3

Molecular Formula

C17H14ClN3O

Molecular Weight

311.77

Precautions

P260-P280-P405-P501

References & Citations

[1]Jie Chen, et al. Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells. Nat Commun. 2021 Oct 27;12 (1) :6204.